ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer
Identifieur interne : 000270 ( Main/Exploration ); précédent : 000269; suivant : 000271ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer
Auteurs : Roxsan Manshouri [États-Unis] ; Etienne Coyaud ; Samrat T. Kundu [États-Unis] ; David H. Peng [États-Unis] ; Sabrina A. Stratton [États-Unis] ; Kendra Alton [États-Unis] ; Rakhee Bajaj [États-Unis] ; Jared J. Fradette [États-Unis] ; Rosalba Minelli [États-Unis] ; Michael D. Peoples [États-Unis] ; Alessandro Carugo [États-Unis] ; Fengju Chen [États-Unis] ; Christopher Bristow [États-Unis] ; Jeffrey J. Kovacs [États-Unis] ; Michelle C. Barton [États-Unis] ; Tim Heffernan [États-Unis] ; Chad J. Creighton [États-Unis] ; Brian Raught ; Don L. Gibbons [États-Unis]Source :
- Nature Communications [ 2041-1723 ] ; 2019.
Abstract
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, due in part to the propensity of lung cancer to metastasize. Aberrant epithelial-to-mesenchymal transition (EMT) is a proposed model for the initiation of metastasis. During EMT cell-cell adhesion is reduced allowing cells to dissociate and invade. Of the EMT-associated transcription factors, ZEB1 uniquely promotes NSCLC disease progression. Here we apply two independent screens, BioID and an Epigenome shRNA dropout screen, to define ZEB1 interactors that are critical to metastatic NSCLC. We identify the NuRD complex as a ZEB1 co-repressor and the Rab22 GTPase-activating protein TBC1D2b as a ZEB1/NuRD complex target. We find that TBC1D2b suppresses E-cadherin internalization, thus hindering cancer cell invasion and metastasis.
Url:
DOI: 10.1038/s41467-019-12832-z
PubMed: 31719531
PubMed Central: 6851102
Affiliations:
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Duncan Comprehensive Cancer Center,</institution><institution>Baylor College of Medicine,</institution></institution-wrap>Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Raught, Brian" sort="Raught, Brian" uniqKey="Raught B" first="Brian" last="Raught">Brian Raught</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2157 2938</institution-id><institution-id institution-id-type="GRID">grid.17063.33</institution-id><institution>Department of Medical Biophysics, Princess Margaret Cancer Centre,</institution><institution>University of Toronto,</institution></institution-wrap>Toronto, ON M5S 1A1 Canada</nlm:aff><wicri:noCountry code="subfield">ON M5S 1A1 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Gibbons, Don L" sort="Gibbons, Don L" uniqKey="Gibbons D" first="Don L." last="Gibbons">Don L. 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Kundu</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Department of Thoracic/Head and Neck Medical Oncology,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Department of Molecular and Cellular Oncology,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Peng, David H" sort="Peng, David H" uniqKey="Peng D" first="David H." last="Peng">David H. Peng</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Department of Thoracic/Head and Neck Medical Oncology,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Department of Molecular and Cellular Oncology,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Stratton, Sabrina A" sort="Stratton, Sabrina A" uniqKey="Stratton S" first="Sabrina A." last="Stratton">Sabrina A. Stratton</name><affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Department of Epigenetics and Molecular Carcinogenesis,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Alton, Kendra" sort="Alton, Kendra" uniqKey="Alton K" first="Kendra" last="Alton">Kendra Alton</name><affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Department of Epigenetics and Molecular Carcinogenesis,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Bajaj, Rakhee" sort="Bajaj, Rakhee" uniqKey="Bajaj R" first="Rakhee" last="Bajaj">Rakhee Bajaj</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Department of Thoracic/Head and Neck Medical Oncology,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Department of Molecular and Cellular Oncology,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Fradette, Jared J" sort="Fradette, Jared J" uniqKey="Fradette J" first="Jared J." last="Fradette">Jared J. Fradette</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Department of Thoracic/Head and Neck Medical Oncology,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Department of Molecular and Cellular Oncology,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Minelli, Rosalba" sort="Minelli, Rosalba" uniqKey="Minelli R" first="Rosalba" last="Minelli">Rosalba Minelli</name><affiliation wicri:level="2"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Department of Cancer Genomics,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Peoples, Michael D" sort="Peoples, Michael D" uniqKey="Peoples M" first="Michael D." last="Peoples">Michael D. Peoples</name><affiliation wicri:level="2"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Department of Cancer Genomics,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Carugo, Alessandro" sort="Carugo, Alessandro" uniqKey="Carugo A" first="Alessandro" last="Carugo">Alessandro Carugo</name><affiliation wicri:level="2"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Institute for Applied Cancer Science,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Chen, Fengju" sort="Chen, Fengju" uniqKey="Chen F" first="Fengju" last="Chen">Fengju Chen</name><affiliation wicri:level="2"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id><institution-id institution-id-type="GRID">grid.39382.33</institution-id><institution>Department of Medicine and Dan L. Duncan Comprehensive Cancer Center,</institution><institution>Baylor College of Medicine,</institution></institution-wrap>Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Bristow, Christopher" sort="Bristow, Christopher" uniqKey="Bristow C" first="Christopher" last="Bristow">Christopher Bristow</name><affiliation wicri:level="2"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Institute for Applied Cancer Science,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Kovacs, Jeffrey J" sort="Kovacs, Jeffrey J" uniqKey="Kovacs J" first="Jeffrey J." last="Kovacs">Jeffrey J. Kovacs</name><affiliation wicri:level="2"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Institute for Applied Cancer Science,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Barton, Michelle C" sort="Barton, Michelle C" uniqKey="Barton M" first="Michelle C." last="Barton">Michelle C. Barton</name><affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Department of Epigenetics and Molecular Carcinogenesis,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Heffernan, Tim" sort="Heffernan, Tim" uniqKey="Heffernan T" first="Tim" last="Heffernan">Tim Heffernan</name><affiliation wicri:level="2"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Institute for Applied Cancer Science,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Creighton, Chad J" sort="Creighton, Chad J" uniqKey="Creighton C" first="Chad J." last="Creighton">Chad J. Creighton</name><affiliation wicri:level="2"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2160 926X</institution-id><institution-id institution-id-type="GRID">grid.39382.33</institution-id><institution>Department of Medicine and Dan L. Duncan Comprehensive Cancer Center,</institution><institution>Baylor College of Medicine,</institution></institution-wrap>Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author><author><name sortKey="Raught, Brian" sort="Raught, Brian" uniqKey="Raught B" first="Brian" last="Raught">Brian Raught</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2157 2938</institution-id><institution-id institution-id-type="GRID">grid.17063.33</institution-id><institution>Department of Medical Biophysics, Princess Margaret Cancer Centre,</institution><institution>University of Toronto,</institution></institution-wrap>Toronto, ON M5S 1A1 Canada</nlm:aff><wicri:noCountry code="subfield">ON M5S 1A1 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Gibbons, Don L" sort="Gibbons, Don L" uniqKey="Gibbons D" first="Don L." last="Gibbons">Don L. Gibbons</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Department of Thoracic/Head and Neck Medical Oncology,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2291 4776</institution-id><institution-id institution-id-type="GRID">grid.240145.6</institution-id><institution>Department of Molecular and Cellular Oncology,</institution><institution>The University of Texas MD Anderson Cancer Center,</institution></institution-wrap>Houston, TX 77030 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Houston</wicri:cityArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, due in part to the propensity of lung cancer to metastasize. Aberrant epithelial-to-mesenchymal transition (EMT) is a proposed model for the initiation of metastasis. During EMT cell-cell adhesion is reduced allowing cells to dissociate and invade. Of the EMT-associated transcription factors, ZEB1 uniquely promotes NSCLC disease progression. Here we apply two independent screens, BioID and an Epigenome shRNA dropout screen, to define ZEB1 interactors that are critical to metastatic NSCLC. We identify the NuRD complex as a ZEB1 co-repressor and the Rab22 GTPase-activating protein TBC1D2b as a ZEB1/NuRD complex target. 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Si</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Lmn" uniqKey="Wu L">LMN Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verstappen, G" uniqKey="Verstappen G">G Verstappen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vrba, L" uniqKey="Vrba L">L Vrba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carroll, B" uniqKey="Carroll B">B Carroll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frasa, Mam" uniqKey="Frasa M">MAM Frasa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Rien, Td" uniqKey="O Rien T">TD O’Brien</name></author><author><name sortKey="Jia, P" uniqKey="Jia P">P Jia</name></author><author><name sortKey="Caporaso, Ne" uniqKey="Caporaso N">NE Caporaso</name></author><author><name sortKey="Landi, Mt" uniqKey="Landi M">MT Landi</name></author><author><name sortKey="Zhao, Z" uniqKey="Zhao Z">Z Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Magadan, Jg" uniqKey="Magadan J">JG Magadán</name></author><author><name sortKey="Barbieri, Ma" uniqKey="Barbieri M">MA Barbieri</name></author><author><name sortKey="Mesa, R" uniqKey="Mesa R">R Mesa</name></author><author><name sortKey="Stahl, Pd" uniqKey="Stahl P">PD Stahl</name></author><author><name sortKey="Mayorga, Ls" uniqKey="Mayorga L">LS Mayorga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weigert, R" uniqKey="Weigert R">R Weigert</name></author><author><name sortKey="Yeung, Ac" uniqKey="Yeung A">AC Yeung</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Donaldson, Jg" uniqKey="Donaldson J">JG Donaldson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marlin, Mc" uniqKey="Marlin M">MC Marlin</name></author><author><name sortKey="Li, G" uniqKey="Li G">G Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Naj, X" uniqKey="Naj X">X Naj</name></author><author><name sortKey="Linder, S" uniqKey="Linder S">S Linder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peinado, H" uniqKey="Peinado H">H Peinado</name></author><author><name sortKey="Olmeda, D" uniqKey="Olmeda D">D Olmeda</name></author><author><name sortKey="Cano, A" uniqKey="Cano A">A Cano</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Coyaud, E" uniqKey="Coyaud E">E Coyaud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langmead, Ben" uniqKey="Langmead B">Ben Langmead</name></author><author><name sortKey="Trapnell, Cole" uniqKey="Trapnell C">Cole Trapnell</name></author><author><name sortKey="Pop, Mihai" uniqKey="Pop M">Mihai Pop</name></author><author><name sortKey="Salzberg, Steven L" uniqKey="Salzberg S">Steven L Salzberg</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><noCountry><name sortKey="Coyaud, Etienne" sort="Coyaud, Etienne" uniqKey="Coyaud E" first="Etienne" last="Coyaud">Etienne Coyaud</name><name sortKey="Raught, Brian" sort="Raught, Brian" uniqKey="Raught B" first="Brian" last="Raught">Brian Raught</name></noCountry><country name="États-Unis"><region name="Texas"><name sortKey="Manshouri, Roxsan" sort="Manshouri, Roxsan" uniqKey="Manshouri R" first="Roxsan" last="Manshouri">Roxsan Manshouri</name></region><name sortKey="Alton, Kendra" sort="Alton, Kendra" uniqKey="Alton K" first="Kendra" last="Alton">Kendra Alton</name><name sortKey="Bajaj, Rakhee" sort="Bajaj, Rakhee" uniqKey="Bajaj R" first="Rakhee" last="Bajaj">Rakhee Bajaj</name><name sortKey="Bajaj, Rakhee" sort="Bajaj, Rakhee" uniqKey="Bajaj R" first="Rakhee" last="Bajaj">Rakhee Bajaj</name><name sortKey="Barton, Michelle C" sort="Barton, Michelle C" uniqKey="Barton M" first="Michelle C." last="Barton">Michelle C. 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Kundu</name><name sortKey="Manshouri, Roxsan" sort="Manshouri, Roxsan" uniqKey="Manshouri R" first="Roxsan" last="Manshouri">Roxsan Manshouri</name><name sortKey="Minelli, Rosalba" sort="Minelli, Rosalba" uniqKey="Minelli R" first="Rosalba" last="Minelli">Rosalba Minelli</name><name sortKey="Peng, David H" sort="Peng, David H" uniqKey="Peng D" first="David H." last="Peng">David H. Peng</name><name sortKey="Peng, David H" sort="Peng, David H" uniqKey="Peng D" first="David H." last="Peng">David H. Peng</name><name sortKey="Peoples, Michael D" sort="Peoples, Michael D" uniqKey="Peoples M" first="Michael D." last="Peoples">Michael D. Peoples</name><name sortKey="Stratton, Sabrina A" sort="Stratton, Sabrina A" uniqKey="Stratton S" first="Sabrina A." last="Stratton">Sabrina A. Stratton</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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